Tetracycline is used in general practice mainly for the treatment of chest and soft tissues infections. It is also the drug of choice in infections of the CNS, and in: infections of the urinary tract caused by klebsiella spp. and Esch. Coli.
The usual dose of Tetracycline hydrochloride is 250mg to 500mg 6 hourly by mouth preferably one hr before or 2 hrs after meals. Higher doses up to 3 or 4 grammes have occasionally been given in resistance infection.
Tetracycline capsules should not be taken with milk or antacids because of complex formation that make the absorption of the drugs from G.I.T to be very poor.
G.I.T disturbances with flatulence, nausea, vomiting and diarrhea. Angular stomatitis, glossitis, rectal and vaginal irritation. Drug fever and allergic skin rashes may occur on rare occasions, but can be controlled by the administration of anti histamines.
Tetracycline is contra indicated in patients with renal impairment. It is also not to be administered during pregnancy or to children less than 7 years of age.
Tetracycline should be stored in a cool dry place at a temperature below 30oc. keep all medicines out of the reach of children.