PETSIDER

Description

Petsidar is indicated in treatment of all types of malaria due to plasmodium falciparum, plasmodium ovale, and plasmodium malaria and plasmodium vivax in area of high chloroquine resistance in some patients.
CONTRA-INDICATIONS: Petsidar is contra-indicated in patients with known hypersensitivity to sulfonamides or pyrimethamine; severe heptic or renal impairment. Petsidar should not be given for prophylaxis in the first trimester for malarial attack in pregnancy. The risk should be weighed against the expected benefits before administration. Petsidar is also contra-indicated in premature and new born infants due to their poorly matured enzymes system. It should also not be given prophylactically in the last weeks of pregnancy.
ROUTE OF ADMINISTRATION: Oral
DOSAGE & CONDITION OF ADMINISTRATION:
1. CURATIVE :(Adults) Depends on body weight.2 to 3 tablets at once.
(children) 9-14yrs: 2 tablets
4-8yrs: 1 tablet
Under 4 yrs: ½ tablet
Please note that dose should not be repeated for at least 7 days
2. PROPHYLAXIS: Dose to be taken every 7 days.
(Adult): 1 tablet every 7 days.
(Children) 9-14 yrs: 3/4 tablet
4-8yrs: ½ tablet
Under 4 yrs: ¼ tablet
SIDE EFFECTS: Petsidar is generally well tolerated at recommended doses, However, administration for prolonged periods mau cause depression of haematopoisis due to interference with folic acid metabolism. Skin rashes, insomnia and hypersentivity reactions can also occur. Other side effects include nausea, vomiting, anorexia and diarrhea.
INTERACTIONS: Petsidar administration along with trimetoprim or Cotrimoxazole can can result in increased interference with folic acid metabolism and consequently heamatological side effects. And hould therefore be avoided. The co-administration of petsidar with chloroquine may increase the incidence of side effects.
ANTIDOTE IN OVER-DOSE: Treatment of petsidar over dosage is sympyomatic. The first step is to discontinue treatment immediately if any skin reaction, sore throat, or shortness of breath occurs.
The risk of crystal ura can be reduced by the administration of fluid to maintain a high level urine output. Alkalization of urine by administering sodium bicarbonate may be necessary to increase the solubility and elimination of sulphadoxine. Forced diures and vigorous gastric lavage should be carried out as early as possible after ingestion.
ADVICE TO PATIENTS: Drink plenty of fluids, avoid prolonged exposure to the sun, and consult the physician if rash, sore throat, or shortness of breath, or glossitis occur.
STORAGE: Petsidar should be stored in a cool, dry place, and away from sunlight and heat.
Keep all medicines out of the reach of children.