Acute and chronic bronchitis, pneumonia, bronchopneumonia, lung abscess, tonsillitis, sinusitis, laryngitis, lurethritis, cystitis, nephritis, typhoid fever bacillary dysentery, boils, carbuncle infected wound, impetigo, gonococcal infections, pre and post-operative control of infections; endocarditis and osteomyelitis.
The usual oral dose is amoxicillin 250mg to 500mg every 8 hours. Children up to 10 years of age may be given 125mg to 250mg every 8 hours; under 20kg body weight, a dose of 20 to 40mg per kg daily has been suggested. For the treatment of Gonorrhea, a dose of 3mgs is recommended.
Skin rashes are among the most common side-effects and are generally either uticarial or maculopapular. Gastro-intestinal adverse effects such as diarrhoea, nausea and vomiting usually occur following the administration by mouth. Pseudo membranous colitis has also been reported.
Amoxicillin is contra-indicated in patients with history of allergic reaction to Penicillin. Amoxicillin should be discontinued if skin rashes occur. It should preferably not be given to patients with infectious mononucleosis since they are especially susceptible to amoxicillin induced skin rashes. Patients with lymphatic leukemia or HIV infection may also be at increased risk of developing skin rashes.
As with any other potent drug, haemopoietic, hepatic and renal function must be assessed periodically whenever treatment is given over a prolonged period. It should be used with caution in patients with known histories of allergy.
USAGE IN PREGNANCY:
Safety during pregnancy has not been established.
Store in a cool, dry place at a temperature below 30oC.